关键词:
超声心动描记术
高铁血红蛋白
纳米技术
纳米结构
纳米粒子
输血
血红蛋白类
氧
综述
摘要:
Due to the continuously insufficient supply and the disadvantages associated with the donated blood,artificial blood substitute has received extensive attentions throughoutthe world in ***-structured hemoglobin-based oxygen carriers (NHOCs),in particular the liposome-encapsulated hemoglobin (LEH) and hemo-globin-based polymeric nanoparticles (HbPNPs),which combine the nanotechnology with the traditional cellular oxygen carriers,have shown great potential applications in blood transfusion,thrombus and cancer therapy as *** present article firstly reports on the current status of the synthesis,properties,clinical trial and application of the LEHand *** then,attentions are devoted to highlight the main challenges and the proposed strategies of the NHOCs with the respect of suppression of the methemoglobin formation and prolonging the blood circulation *** results make us confident in advancing further development of NHOCs,with the expectation of their eventual commercialization.